Guard began his boxing career at the tender age of 12, compiling a combined amateur and professional record of 154 wins and 30 losses before retiring in 1953. Wyatt was instrumental in the boxing careers of Pappy Gault, Ray Lancaster and Charlie Porter.
After retirement, he worked as an electrician. He became the maintenance supervisor at Dorman High School and worked there until 1985 when he again retired. Guard and his wife Jeanette have one daughter.